Clindamycin

An antibiotic that fights bacteria by preventing them from producing essential proteins.

Treatment of bacterial vaginosis (BV) in women, often involving mixed anaerobic and aerobic bacterial infections.

Treatment of skin infections involving both bacteria and fungi (mixed infections).

This combination therapy leverages the synergistic effects of its components. Clindamycin targets bacteria, Metronidazole targets anaerobic bacteria, and Clotrimazole targets fungi. This approach is particularly effective against mixed infections involving multiple pathogens, as seen in BV or some skin infections. The precise mechanism varies depending on the specific pathogen involved and may involve inhibition of protein synthesis (clindamycin), DNA damage (metronidazole), and disruption of fungal cell membranes (clotrimazole).

Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children. Discard any unused medication after the expiration date.

Dosage should always be determined by a healthcare professional based on the specific infection and patient factors.

Common regimens may involve a single dose or a short course of treatment (e.g., 7 days).

Follow the prescribed dosage and frequency precisely; do not exceed the recommended dose.

Gastrointestinal upset (nausea, vomiting, diarrhea)

Vaginal irritation or itching

Headache

Allergic reactions (rash, hives, swelling)

Pseudomembranous colitis (rare but serious complication)

Changes in taste (metallic taste)

Dark urine

Alcohol Consumption

Avoid alcohol consumption during treatment, as it can interact negatively with metronidazole, potentially causing nausea, vomiting, and flushing.



While Driving or operating Machinery

May cause drowsiness or dizziness in some individuals. Avoid operating machinery or driving if affected.



Pregnant & Breastfeeding Women

Consult a healthcare professional before use, as the safety of this combination during pregnancy and breastfeeding hasn't been fully established.



Children

Not usually recommended for children unless specifically prescribed by a pediatrician.



Kidney

Patients with impaired kidney function may require dosage adjustment. Consult your doctor.



Liver

Patients with impaired liver function may require dosage adjustment. Consult your doctor.

Package insert of the specific medication.

A reputable medical website such as the Mayo Clinic or NHS website.

Your physician or pharmacist