Isoniazid

An antibiotic that specifically targets mycobacterium tuberculosis, the bacteria responsible for tuberculosis (tb).

Rifampicin

Another antibiotic effective against mycobacterium tuberculosis. it also works against other bacteria.

Treatment of active pulmonary tuberculosis (TB)

Treatment of active extrapulmonary tuberculosis (TB)

Prophylaxis (prevention) of tuberculosis in individuals with highrisk exposure (e.g., close contacts of TB patients)

Treatment of latent tuberculosis infection (LTBI) – often in combination with other drugs

Isoniazid inhibits the synthesis of mycolic acids, essential components of the Mycobacterium tuberculosis cell wall. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing bacterial protein synthesis and replication.

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children. Discard any unused medication after the expiry date.

Dosage is determined by the physician based on the patient's age, weight, and condition.

The medication is typically taken orally, usually once daily or as directed by a healthcare professional.

It is crucial to complete the entire course of treatment as prescribed, even if symptoms improve, to prevent drug resistance.

Jaundice (yellowing of the skin or eyes)

Peripheral neuropathy (numbness or tingling in the extremities)

Nausea

Vomiting

Abdominal pain

Loss of appetite

Dark urine

Lightcolored stools

Fatigue

Headache

Dizziness

Rash

Itching

Druginduced hepatitis

Alcohol Consumption

Alcohol consumption may increase the risk of liver damage. Consult your doctor.



While Driving or operating Machinery

May cause dizziness or drowsiness. Avoid driving or operating machinery if affected.



Pregnant & Breastfeeding Women

Use only as directed by a doctor. It can cross the placenta and may be excreted in breast milk. The benefits must outweigh the potential risks.



Children

Dosage adjustments are necessary for children. A doctor should determine the appropriate dose.



Kidney

Dosage adjustments may be necessary in patients with kidney impairment.



Liver

Liver function tests should be monitored regularly, particularly during the initial phase of treatment, due to the potential risk of hepatotoxicity.

Your physician

The prescribing information for the specific medication brand

Reputable medical websites (e.g., CDC, WHO)